FHIT and colorectal carcinoma: Further, a comparison of the clinical profile with the combinatorial effect of variations in genes in 62 patients with sporadic CRC was performed and it was observed that the clinical features were more commonly observed in patients with increasing number of variation in the genes in terms of genetic mutation in Kras gene and/or promoter hypermethylation in MGMT, FHIT and RASSF1A genes in sporadic CRC (Table 5).