Studies have shown that genetic deficiency of ADORA2B increased the death rate of mice suffering from cecal ligation and puncture-induced sepsis, and the increased mortality of ADORA2B knockout mice may be associated with increased levels of inflammatory cytokines, chemokines, augmented NF-κB and p38 activation in the spleen, heart, and plasma [33]. The gene discussed is NFKB1; the disease is Sepsis.