Furthermore, we performed in vitro experiments to test whether the IL-17A present in induced sputum (Ss) and in NW may compromise the release of IL-8 from bronchial and nasal airway epithelial cells, and whether the intracellular IL-17A expressed in T-cells from children with asthma and AR is involved in the Th17/Treg balance. The gene discussed is IL17A; the disease is asthma.