EGFR and neoplasm: For example, imatinib causes dramatic tumor regression in gastrointestinal stromal tumors (GIST) [2, 3] and chronic myelogenous leukemia (CML) [3–5] by inhibiting the Bcr-Abl oncogene; erlotinib and gefitinib cause dramatic tumor regression in nonsmall cell lung cancer (NSCLC) [6–9], pancreatic cancer, and other tumors by inhibiting EGFR; a number of other examples of targeted therapies exist.