TNFRSF1A and cancer: Upon binding of its cellular TNF-α receptor 1 (TNFR1), it induces apoptosis of cancer cells by either recruitment of TNFR-associated death domain (TRADD), and Fas-associated protein with death domain (FADD) [2, 3] or activation of reactive oxygen species (ROS) and cytochrome c release from mitochondria [4].