ICAM1 and lung cancer: MMP-9 plays a crucial role in tumor invasion and angiogenesis by mediating degradation of the extracellular matrix [51], and inhibition of MMP-9 activity has been shown to suppress nonsmall-cell lung cancer (H1299) metastasis in nude mice xenografts [52], while ICAM-1 activation is found to contribute migration of human lung cancer cells [53].