Induction of TRAIL-R1 and TRAIL-R2 expression and caspase-8, -10, -9, -3 activation in SW-480 colon cancer cells and activation of caspase-8, suppression of Akt, survivin, XIAP, and antiapoptotic mitochondrial proteins from Bcl-2 family: Bcl-2, Bcl-xL, Mcl-1 in U251 and U87 glioma cells by kaempferol are sufficient to restore TRAIL sensitivity [78, 79]. The gene discussed is CASP8; the disease is central nervous system cancer.