Apigenin augments TRAIL-induced apoptosis in Jurkat leukemia T cells, DU145 prostate cancer cells, and DLD-1 colon cancer cells through upregulation of TRAIL-R2, activation of Bid and caspase-8, -10, -9, -3 [71]. The gene discussed is TNFSF10; the disease is malignant colon neoplasm.