Chrysin and apigenin overcome TRAIL-resistance in MDA-MB-231 breast cancer cells, HT-29 colon cancer cells, HepG2 hepatocellular cancer cells, SK-MEL-37 melanoma cells, Capan-1 pancreatic cancer cells via increased expression of TRAIL-R2 and decreased expression of FLIP [69]. Here, TNFRSF10B is linked to colonic neoplasm.