PTGS2 and colonic neoplasm: It was demonstrated that pretreatment of a colon cancer cell line with commercial PG juice (6–50 μg/mL), total pomegranate tannins (TPT, 30–200 μg/mL), and punicalagin (25–200 μg/mL) inhibited AKT activity, NF-κB activation, and COX-2 expression induced by TNFα [40].