Resveratrol exhibits remarkable biological activities in metabolic diseases, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMPK and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) activity, increased mitochondrial number, and improved motor function [24–26]. This evidence concerns the gene IGF1 and metabolic disease.