At the level of the pancreatic islets, 1,25(OH)2D3 decreased in vivo and in vitro proinflammatory chemokine and cytokine expression (e.g., IL6), which are implicated in the pathogenesis of T1DM making β-cells less chemoattractive and less prone to inflammation; this results in decreased T cell recruitment and infiltration, increased regulatory cells, and arrest of the autoimmune process [15–17]. Here, IL6 is linked to type 1 diabetes mellitus.