These results were homogeneous in the whole group of patients, regardless of the clinical parameters, such as stage of disease according to Rai and Binet, the absolute count of lymphocytes, lymphocyte doubling time, prior chemotherapeutic treatment, age, gender, cell morphology, immunoglobulin levels, autoimmunity, and the expression of ZAP70 and CD38 [24]. This evidence concerns the gene CD38 and Autoimmunity.