There were increased protein expressions of angiotensinogen predominantly in the proximal tubular cells, angiotensin II in both glomerular and tubular cells, renin in juxtaglomerular apparatus cells, ACE mainly in brush border membranes of proximal tubules, and AT1 and AT2 in glomeruli and proximal tubules in the HF group when compared to the control group (Figure 3A). Here, ACE is linked to hydrops fetalis.