TP53 and cancer: The genes that encode the negative cell cycle regulators Cdkn2b [13,16] or Cdkn1a [24,25] have been validated as direct MIZ-1 targets, and c-Myc has been shown to be recruited to the Cdkn1a promoter by MIZ-1; this interaction blocks Cdkn1a induction by p53 and other activators in cancer cells [13,16,24,25].