TNF and diabetes mellitus: An inflammatory imbalance, as manifested by increased pro-inflammatory cytokines, such as the tumor necrosis factor alpha (TNF-α), increased C-reactive protein (hsCRP), and/or reduced levels of anti-inflammatory and anti-atherogenic mediators, such as adiponectin, have been considered a key factor for the increased CVR in some pathologies [22,23], deserving more attention in respect to the gender and menopause, mainly in diabetes.