TLR2 and amyotrophic lateral sclerosis: SH-SY5Y neuroblastoma cells transfected with the G93A mutant of SOD1 (which is typical of familial ALS) were more vulnerable to the neurotoxic action of pneumolysin and to the attack of monocytes stimulated by Pam3CSK4 and TLR-2 agonist than SH-SY5Y cells transfected with wild-type human SOD1 [29].