CASP3 and amyotrophic lateral sclerosis: In an ALS-like transgenic mouse model, the reduction of GSH in the spinal cord and motor neuron cells is correlated with apoptosis-inducing factor translocation, caspase-3 activation, and motor neuron degeneration during ALS-like disease onset and progression [142], suggesting that decreased GSH promotes multiple apoptotic pathways that contribute to motor neuron degeneration in ALS.