SGSH and mucopolysaccharidosis type 3A: Furthermore, the fact that treatment with fully modified sulphamidase reduced hyperactivity in MPS-IIIA female mice but increased hypoactivity in MPS-IIIA male mice suggests that this treatment is not broadly modulating the general level of activity in MPS-IIIA mice, but that it is specifically modulating the neuropathological mechanism underlying the gender specific phenotype of MPS-IIIA.