The concentrations of TNF-α, IFN-γ and IL-1β inducing an increase in IL-33 production in those cells in vitro were higher than plasma concentrations of these cytokines measured in patients suffering from various cardiovascular diseases such as heart failure, myocardial infarction, or unstable angina [44], [45], [46]. The gene discussed is IL1B; the disease is angina pectoris.