PHB1 and polycystic ovary syndrome: The role of PHB in the regulation of apoptosis, steroidogenesis as well as proliferation [11,12], the dysregulation of ovarian follicular growth and steroidogenesis in polycystic ovarian syndrome (PCOS) [26-28], together with the observations that the expression of PHB increased in a chronically androgenized rat PCOS model [23] suggest a possibility that dysregulation of PHB may be relevant to the etiology of this syndrome.