However, 4 months later (that is, 5 months post-immunization), the level of anti-CL(β2-GPI) was significantly higher in the female(0.48 ± 0.16) than in the male (0.21 ± 0.08) FVL-APS mice, (P = 0.037 for sex effect, ANOVA). Here, APOH is linked to autoimmune polyendocrinopathy.