GPI and autoimmune polyendocrinopathy: At 1 month after APS induction, high levels of β2-GPI-dependent anti-CL (anti-CL(β2-GPI)) antibodies were found in all APS-immunized mice compared with adjuvant-immunized (control) naïve and FVL mice (P < 0.001 for the effect of immunization by ANOVA) (Figure 1A).