Following these encouraging data, several phase 3 RA trials have been initiated: two in patients with inadequate response to methotrexate (STAGE, ClinicalTrials.gov: NCT00406419; FEATURE, ClinicalTrials.gov:NCT 00673920), one testing ocrelizumab in conjunction with methotrexate in methotrexate-naïve patients (FILM, ClinicalTrials.gov:NCT00485589), and one testing ocrelizumab in patients with an inadequate response to at least one TNF inhibitor (SCRIPT, ClinicalTrials.gov: NCT 00- 4 76996) [113-115]. Here, TNF is linked to rheumatoid arthritis.