So in this study, we decided to investigate the association of polymorphisms in the enzymes involved in general oxidative stress defence including NAD(P)H:quinone oxidoreductase-1 (NQO1), Glutathione S-transferases (GST) M1 and T1, and microsomal epoxide hydrolase (EPHX1) enzymes and the two most important cytokines involved in the pathogenesis of liver disease with the basis of inflammation, namely tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) cytokines and the treatment outcome of silymarin in the subjects chronically exposed to H2S. Here, EPHX1 is linked to liver disorder.