Although no significant association was found between combined COMT/OPRM1 genotypes and the incidence of chronic postsurgical pain in our study population, the CPP patients with Met158Met/A118G had higher pain scores than those patients with Val158Val/A118A, Met158Val/A118A, and Met158Met/A118A. The gene discussed is OPRM1; the disease is central precocious puberty.