When comparing results to our previous proteomic studies of other MDS subgroups (refractory cytopenia with multilineage dysplasia and refractory anemia with excess blasts subtype 1), there are agreements in some results, especially in changes in the composition or modification of fragments of inter-alpha-trypsin inhibitor heavy chain H4 protein. This evidence concerns the gene ITIH4 and myelodysplastic syndrome with single lineage dysplasia.