The relative label-free quantification (together with absolute quantification and 2D electrophoresis data) also suggests a possible role of PTM(s) of alpha-2-HS-glycoprotein, a protein related to bone marrow development and function, in MDS patients with refractory anemia and refractory anemia with ringed sideroblasts. This evidence concerns the gene AHSG and myelodysplastic syndrome with single lineage dysplasia.