They limit signal transmission from membrane receptors and slow down pathologic remodeling of the heart and vessels, inhibit the action of angiotensin II, inhibit apoptosis, improve endothelial function, retard the progression of heart failure symptoms, reduce the level of N-terminal pro-brain natriuretic peptide (NT-proBNP), restore autonomic nervous system balance and might have a protective influence on renal function and blood pressure [7,8]. Here, NPPB is linked to heart failure.