According to the multivariate regression analysis we found that NT-proBNP (odds ratio [OR] 1.00, p = 0.007) and LVdD (OR 2.96, p = 0.025) were the independent risk factors of death, and 6-MWT (OR 0.99, p = 0.001) was the only independent risk factors of re-hospitalization for worsening heart failure. The gene discussed is NPPB; the disease is heart failure.