VAV3 and neoplasm: Representative immunohistochemical staining of Ki-67, pAR, and M30 CytoDeath is shown in Figure 5D, and the immunohistochemical findings are summarized in Figure 5E. The mean percentage of Ki-67-positive tumor cells in si-Vav3- or docetaxel-treated tumors was significantly decreased compared with that in control tumors (42 ± 8% and 11 ± 5%, respectively, versus 82 ± 10%, P < 0.005), and an even more significant reduction was observed in tumors treated with si-Vav3 plus docetaxel (7 ± 3%, P < 0.005).