Among the TFs from the significant TF-target functional modules, signal transducer and activator of transcription 4 (STAT4), androgen receptor (AR), pre-B-cell leukemia transcription factor 1 (PBX1), and paired box 6 (PAX6) are matched with T2D-related genes. The gene discussed is PBX1; the disease is type 2 diabetes mellitus.