This has been reported after parenteral administration of aluminum.212 However, iCa was not measured in this study and a different study actually showed that iCa decreased slightly after parenteral infusion of aluminum in dogs while the total calcium increased.213 Hypophosphatemia and low PTH have been rarely described in cats and dogs on a low phosphate diet that developed ionized hypercalcemia; the hypercalcemia resolved when fed a higher dietary phosphorus.111,136 The mechanism for the hypercalcemia in this instance may have been due to adynamic bone due to excessive suppression of PTH. This evidence concerns the gene PTH and Hypercalcemia.