Increases in PTH were demonstrated even during early stages of nephron reduction (1/3, 2/3, 5/6 & 11/12 partial nephrectomy).121 A parathyroidectomy/nephrectomy model was also studied to see its effects on survival and renal function of dogs with induced CKD.122 The parathyroidectomy group had lower mortality and greater stabilization of GFR that approached statistical significance (P < 0.06) between 12 and 24 months, better-preserved bone mineralization, and less severe soft tissue mineralization. Here, PTH is linked to chronic kidney disease.