Serum phosphorus was not significantly different between treatment groups, and dogs in both groups received intestinal phosphorus binders.146 Similar results for survival and preservation of renal function (based on serum creatinine concentration) were obtained in cats with IRIS stage 2 and 3 spontaneous CKD treated with a renal or maintenance diet.147 PTH concentrations were increased at baseline in both treatment groups and did not differ throughout the 24 months of this study. The gene discussed is PTH; the disease is chronic kidney disease.