In a study which enrolled 84 patients with migraine (73 F, 11 M), 25 patients with non-migraine headache (20 F, 5 M), and 26 healthy subjects (24 F, 2 M), some authors showed the presence of higher levels of insulin in migraine than in other headaches (P < .0001) and controls (P < .0001), and higher levels of blood glucose in headache patients, with a greater difference between migraine and healthy subjects (P < .0001) than between other headaches and controls (P < .05). This evidence concerns the gene INS and Headache.