This study has raised several arguments showing that genetic variations affecting the EGFR polyA repeat are not involved in CRC development: (i) The EGFR polyA polymorphism does not constitute a genetic risk factor for CRC; (ii) somatic mutations of this repeat are commonly observed in MSI CRC, but their frequency reflects a sensitivity of this type of repeat to MSI and not a specific selective advantage; (iii) somatic EGFR polyA mutations do not result into an EGFR mRNA increase in colorectal tissue. The gene discussed is EGFR; the disease is colorectal carcinoma.