However, a significantly shorter 5-year OS was seen for RBM3 negative compared to RBM3 positive tumours in univariable analysis (n=231; HR=2.00 95% CI 1.21-3.33) and borderline significant in multivariable analysis (HR=1.64 95% CI 0.96-2.78) (Table 4). The gene discussed is RBM3; the disease is neoplasm.