ITGB2 and neoplasm: Analogous to the effect of sMICA on NK-cell function [48], [49], it is possible that the secretion of sICAM-1 by human tumours may hinder the interaction between ICAM-1 and CD11b/CD18, leading to the downregulation of CD11b expression on NK cells and thereby affecting the TINK-cell functional maturation.