FOXP3 and hepatocellular carcinoma: Subsequently, we compared different CD4+ T cell subsets and found that the frequencies of IL-17-producing CD4+ T (Th17) cells, IFN-γ-producing CD4+ T (Th1) cells and CD4+CD25+FoxP3+ cells (Treg) were all increased in stage III HCC patients compared with healthy donors (Figure 1).