Comparable to the meta-analysis by Jing et al. [31], Zhang et al. showed that TLR4 Thr399Ile is associated with cancer in general (combining gastric, cervical, colorectal, gallbladder and prostate cancers) showing an OR of 1.81 (95% CI: 1.18–2.77) [27]. This evidence concerns the gene TLR4 and Familial prostate cancer.