PIM1 and prostate neoplasm: However, the expression of Pim1 in human prostate cell lines representing different stages of the disease demonstrated that Pim1 overexpression alone was not sufficient to transform the benign RWPEI cells to malignancy, but Pim1 did enhance the tumorigenic capabilities of LNCaP and Du145 cells in vitro[48] and PC3 prostate tumor cells in vivo[49].