We used the Cre-lox system [7], [17] to create a murine pancreas-specific Cel over-expressing model, the TgCEL, for CEL-MODY by mating floxed STOP-CEL mice to elastase-Cre mice as described in Methods and Fig. 1A. Here, CEL is linked to Chronic Eosinophilic Leukemia, Not Otherwise Specified.