ITGAM and neoplasm: Tumors from mice with Rap1a−/− bone marrow showed significant reductions in the recruitment of total CD11b+Gr1+ myeloid cells (Figure 6C), in the recruitment of monocytic and granulocytic subpopulations (Figure 6D–E) and CD11b+F4/80+ macrophages (Figure 6F) to the tumor microenvironment, as determined by protease-mediated dissolution of tumors and flow cytometric quantification of cell subpopulations.