mTOR is a well-known sensor for extracellular nutrients and growth factors converging many crucial signals e.g. Ras/mitogen-activated protein kinase (MAPK) and PI3K/AKT to control tumor cell growth [43] and is known to regulate fundamental cellular functions inclusive of proliferation/growth, survival, migration, adhesion, autophagy, and metabolism [22]. This evidence concerns the gene MTOR and neoplasm.