First, it has been shown that ATP promotes antitumor immune responses by: 1) enhancing dendritic cell-primed tumor specific CD8 T cell cytotoxicity [9], [10]; 2) acting as a “find-me” signal to phagocytes [11]; 3) induction of IL-1β release by monocytes [12], [13]; 4) skewing of T helper (Th) cells towards type 1 (Th1) and type 17 (Th17) cells which are thought to promote antitumor immunity [14]–[16]; and 5) limiting immunosuppressive activity by induction of regulatory T cell (Treg) apoptosis [17], [18]. Here, CD8A is linked to neoplasm.