Moreover, the global P2 receptor antagonist suramin (inhibiting P2X1–3, P2X5, P2Y1–2, P2Y6, and P2Y11–13) was unable to relieve the suppressive actions of ATP on phosphorylation of AKT, PRAS40 and S6K (Fig. S3B) as well as tumor cell growth (data not shown), although it could block ATP-induced activation of AMPK signaling (Fig. S3B). Here, P2RX5 is linked to neoplasm.