P2RX7 and neoplasm: Strikingly, P2X7 deficiency near fully deviated all cytostatic ATP-mediated effects on tumor cells: signaling regulatory networks (Fig. 4B; Fig. S4B), cell growth (Fig. 4C–E; Fig. S4C–E), colony-forming capacity (Fig. 4F), and autophagy (Fig. 4G; Fig. S4F).