Similar effects were found for the RORA SNP rs9302215, with only marginal main effects on the risk of physician-diagnosed asthma by age 4 years (Files S2, S3, S4), but that in combination with the functional haplotype of NPSR1 might significantly increase the risk for asthma in children (OR 2.88; 1.33–6.23, p = 0.007) (Figure 7c). The gene discussed is NPSR1; the disease is asthma.