The CC genotype in RORA rs7164773 only confers risk for asthma in carriers of one or two copies of the rare allele G in NPSR1 rs6972158, encoding for a substitution of glutamine by arginine in exon 9 (OR 2.45, 1.56–3.85, p = 0.00009) but not in the homozygotes for the wild-type NPSR1 allele A (OR 1.02, 0.66–1.58, p = 0.91). This evidence concerns the gene NPSR1 and asthma.