RORA and asthma: Thus, the aims of this study were: 1) To clarify the potential functional crosstalk between NPSR1 and RORA; 2) To identify the impact of putative RORA risk alleles on the susceptibility to asthma and allergic traits; and 3) To evaluate potential gene-gene interaction (epistasis) between RORA and NPSR1 polymorphisms as risk factors for asthma.