Interestingly, these RORA SNPs did not show any significant main effects on asthma, but they had significant effects on asthma susceptibility dependent on NPSR1. Furthermore, we identified significant interactions between the RORA SNP rs7164773, which showed the most significant SNP main effect on childhood asthma, both at 4 and 8 years in BAMSE, and two coding SNPs in the NPSR1 gene, i.e., rs34705969 (Interaction p = 0.005) and rs6972158 (Interaction p = 0.001). This evidence concerns the gene NPSR1 and asthma.