The fact that NPSR1 stimulation led to up-regulation of RORA mRNA and other clock genes is in agreement with the hypothesis suggesting that alterations in the expression of clock genes might lead to circadian disruption and immune dysregulation in chronic inflammatory diseases such as inflammatory bowel disease [53], [54] and rheumatoid arthritis [55], [56]. The gene discussed is NPSR1; the disease is rheumatoid arthritis.