The results of the genetic association tests and the gene-gene interaction analysis confirmed that polymorphisms in RORA are associated with asthma but their effects may increase or decrease depending on the convergence with polymorphisms in the promoter and the exons of NPSR1. Altogether, this study provides evidence of a previously unknown connection between RORA and NPSR1 that involve the regulation of the circadian clock. The gene discussed is NPSR1; the disease is asthma.