INS and Hyperglycemia: Moreover, glucocorticoids induce pancreatic beta-cell dysfunction by inhibiting several signaling pathways and interfering at several steps in the insulin signaling cascade, particularly those that involve glucose cycling, glucose 6 phosphate, and protein kinase A and C activation (Fig. 1) [25, 26], all which may contribute to the risk of hyperglycemia secondary to hypercortisolism.