Initial studies reported the accumulation of macrophages within adipose tissue and the subsequent liberation of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-α), which contribute to obesity-associated insulin resistance (Weisberg et al., 2003; Xu et al., 2003). The gene discussed is TNF; the disease is obesity disorder.