AR and prostate neoplasm: Consistent and frequent findings from recent genomic profiling studies in clinical metastatic prostate tumors include the TMPRSS2-ERG fusion in approximately 50%, 8p loss in approximately 30% to 50%, 8q gain in approximately 20% to 40% of cases, and the androgen receptor (AR) amplification in approximately 33% of CRPC cases [7-10].