ERG and Familial prostate cancer: (b) In addition, we sequenced with high coverage (approximately 50x) 55 genes frequently mutated in cancer according to the COSMIC [67] and Cancer Gene Census [68] databases (Additional file 1, Table S3), and 38 introns often involved in structural somatic rearrangements, including recurrent gene fusions involving members of the E twenty-six (ETS) family of transcription factors to test for TMPRSS2-ERG-positive prostate cancers (herein referred to as GB-panel (Gene-Breakpoint panel)).