Over-expressing miR-411 in C2C12 cells leads to down-regulation of Myod, myogenin, and Myh1. Based on previous findings as well as our own observations, we propose a potential model of how up-regulation of miR-411 can be involved in the myogenic defect observed in FSHD myoblasts. The gene discussed is MYOG; the disease is facioscapulohumeral muscular dystrophy.