In patient with EOC, it has previously been reported that Ang II enhances vascular endothelial growth factor (VEGF) secretion, angiogenesis and tumor cell invasion via up-regulating G-protein-coupled AT1 receptor; importantly, angiogenesis and peritoneal dissemination of the EOC can selectively be blocked using AT1 receptor antagonist[6,8]. The gene discussed is VEGFA; the disease is neoplasm.