CHF5074 was previously shown to restore the levels of synaptophysin [21], to reduce the accumulation of native hyperphosphorylated tau, and to decrease brain GSK-3β levels, a secondary effect presumably associated with the reduction of intraneuronal Aβ [52], thus suggesting an effect of this molecule on the most relevant molecular players involved in AD pathology. Here, GSK3B is linked to Alzheimer disease.