However, higher proportion of stromal cells were HYAL2 positive (6-25%) in deep melanomas (p=0.028), and the intensity of stromal HYAL2 staining was higher in dysplastic nevi (p=0.006) and in superficial (p=0.006) and deep melanomas (p=0.010) compared to benign nevi. This evidence concerns the gene HYAL2 and melanoma.