GLUD1 and major depressive disorder: Moreover, changes in expression of AMPA and kainate receptors have also been reported in postmortem brains of individuals suffering from ASDs, schizophrenia, major depression and bipolar disorder [91], [92], [93], [94], [95], [96], [97], [98] which has similarity to abnormal AMPA and kainate receptor expression in hippocampus, prefrontal cortex and amygdala that we found in GluD1 knockout mice.