We next determined the level of phosphorylation under GFDS of major signal transduction pathways such as the mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K) and phospholipase Cγ (PLCγ) pathways which control proliferation and cell survival in colon cancer [8], [16], [17], [18]. This evidence concerns the gene WNK2 and malignant colon neoplasm.