We found matches between the transcriptional program of stimulated CLL cells with that of activated B cells (upregulated GLA, CTPS, GFI1, NAMPT, CD63, PDIA4/5/6, ADSL, GART, HPRT1, CCND2, AK2, NME2, GSS, RPA1, YWHAB/G, downregulated BANK1) [34]. Here, HPRT1 is linked to B-cell chronic lymphocytic leukemia.