In agreement with them and several other studies [6], [12], [47], [48], we observed downregulation of CXCR4 (Table 1 and Fig. S3 and S4) correlating with reduced CD62L expression [38], maybe related to altered migration of stimulated CLL cells reported before [38], [47], [48]. This evidence concerns the gene CXCR4 and B-cell chronic lymphocytic leukemia.