While Herishanu et al. [6] and recently Krysov et al. [36] show that both IGHV mutated and IGHV unmutated CLL cells transcriptionally respond to BCR ligation in vitro, other studies reported that IGHV mutated CLL cells poorly respond to IgM stimulation, in contrast to IGHV unmutated CLL cells which do respond [12], [37]–[40]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.