It's reported that blocking the Hh pathway by cyclopamine decreased the activation of oncogenic PI3K/Akt, NF-kB and MAPK pathways, inhibited tumor growth, angiogenesis, and suppressed pancreatic cancer invasion and metastasis through inhibiting EMT in the pancreatic cancer cells [14]–[16]. Here, NFKB1 is linked to pancreatic neoplasm.