Previous studies [12] have found 13 mutations in human Foxp3 gene and are associated with autoimmune diseases Park et al [3] found four Foxp3 SNPs in Crohn's disease with an increased risk for homozygous genotyping, Yang et al [4] demonstrated that Foxp3 -6054 and -3279 polymorphisms were associated with the onset of alopecia areata. Here, FOXP3 is linked to autoimmune disease.