For example, as our laboratory has shown, adenoviral gene transfer of TGFβ1 to the anterior segment of the rat eye results in ocular hypertension, accompanied by aberrant proliferation and migration of corneal endothelial cells and iridocorneal adhesions, reminiscent of peripheral anterior synechiae observed in human patients with closed angle glaucoma [15]. The gene discussed is TGFB1; the disease is ocular hypertension.